Endometriosis affects approximately 1 in 10 women of reproductive age but has been historically underfunded in research. Recent advances include GnRH antagonists (elagolix, relugolix) approved for endometriosis pain, and continuing development of novel mechanisms. For patients with endometriosis, clinical trials for endometriosis offer access to investigational therapies. This guide covers how to find endometriosis trials, active research areas, and resources.
Categories of endometriosis trials
Active endometriosis trials in 2026 include:
Next-generation GnRH antagonists: Beyond elagolix and relugolix, novel formulations and combinations.
Selective progesterone receptor modulators: Drugs targeting progesterone signaling without estrogen suppression.
Anti-inflammatory approaches: Trials targeting inflammation underlying endometriosis pain.
Aromatase inhibitor approaches: Combinations for treatment-resistant disease.
Pain management trials: Specifically targeting endometriosis-associated pain.
Diagnostic biomarker trials: Reducing the long delays in endometriosis diagnosis.
Where to find endometriosis trials
Resources:
- ClinicalTrials.gov
- Endometriosis Foundation of America
- The Endometriosis Association
- Major academic gynecology programs
Typical eligibility
Common inclusion criteria:
- Surgically confirmed endometriosis (some trials require this)
- Specific pain severity
- Reproductive age
Common exclusion criteria:
- Pregnancy or breastfeeding
- Active hormonal therapy that affects the trial
- Recent surgery
Frequently Asked Questions
Do I need surgical confirmation for endometriosis trials?
Many trials require it; some accept clinical diagnosis with imaging.
Are non-hormonal endometriosis trials available?
Yes. Anti-inflammatory and pain-targeted approaches are active research.
Can I be in a trial if I want to get pregnant?
Most trials require contraception. Patients planning pregnancy may need to delay trial participation.
Are biomarker trials worthwhile?
Yes for participants who’d benefit from earlier diagnosis. Endometriosis diagnosis often takes years; biomarkers could shorten this.
How long do endometriosis trials typically last?
Phase 3 pain trials are typically 6-12 months with longer-term extensions.
The bottom line on endometriosis trials
Endometriosis research is expanding with novel hormonal and non-hormonal approaches. Endometriosis Foundation of America and academic gynecology programs provide trial resources.