ADHD treatment has been dominated by stimulants (methylphenidate and amphetamine derivatives) for decades, with non-stimulants (atomoxetine, guanfacine, clonidine, viloxazine) as alternatives. Recent research has focused on novel non-stimulant mechanisms, longer-acting formulations, and approaches addressing the limitations of current treatments. For patients with ADHD seeking alternatives or improvements over current options, clinical trials for adhd may offer access to investigational therapies. This guide covers how to find ADHD trials, active research areas, eligibility considerations, and resources.
Categories of ADHD trials
Active ADHD trials in 2026 include:
Novel non-stimulants: Beyond atomoxetine and viloxazine, new mechanisms targeting different neurotransmitter systems.
Extended-release stimulant formulations: Longer-duration formulations with reduced abuse potential.
Adult ADHD specifically: Trials addressing the unique features of adult ADHD presentation and comorbidities.
ADHD with comorbidities: Specific trials for patients with ADHD plus anxiety, depression, or substance use disorder.
Digital therapeutics: FDA-cleared video game-based therapy (EndeavorRx) and other digital interventions.
Cognitive training and behavioral approaches: Non-pharmacological trials for cognitive symptoms.
Where to find ADHD trials
Resources:
- ClinicalTrials.gov
- CHADD (Children and Adults with Attention-Deficit/Hyperactivity Disorder)
- ADDA (Attention Deficit Disorder Association) for adults
- Major academic psychiatry programs
- NIMH research initiatives
Typical eligibility for ADHD trials
Common inclusion criteria:
- ADHD diagnosis meeting DSM-5 criteria
- Specific symptom severity (ADHD-RS scale or similar)
- Age range matching trial (pediatric, adolescent, adult)
- Stable medications for specified period
Common exclusion criteria:
- Significant other psychiatric conditions (varies by trial)
- Active substance use disorder
- Cardiovascular conditions (especially for stimulant trials)
- Pregnancy
Frequently Asked Questions
Are non-stimulant ADHD trials available?
Yes, with multiple novel mechanisms in development. Important for patients who don’t tolerate stimulants or have contraindications.
Can I participate if I’m on Adderall or Ritalin?
Some trials require washout; others test add-on therapies. Trial-specific.
Are pediatric ADHD trials available?
Yes, with age-specific trials covering children and adolescents.
What about adults with ADHD?
Adult ADHD has substantial trial activity, particularly for comorbidities and novel mechanisms.
How does the DEA scrutiny of ADHD prescribing affect trials?
Clinical trials operate under different rules than routine prescribing. Stimulant access in trials continues with appropriate protocols.
The bottom line on ADHD trials
ADHD research focuses on novel non-stimulants, extended-release formulations, and digital therapeutics. CHADD and academic psychiatry programs provide trial resources. Discuss with your psychiatrist or behavioral health provider as part of treatment planning.