Arthritis supplements have varying evidence depending on type of arthritis. Osteoarthritis (mechanical) and rheumatoid arthritis (autoimmune) have different responses. Best supplements for arthritis includes options with reasonable evidence. Discuss with rheumatologist for inflammatory arthritis.
For osteoarthritis
Turmeric/curcumin: Some evidence for OA pain. 500-1000 mg daily of curcumin extract.
Glucosamine + chondroitin: Mixed evidence; modest effect if any.
MSM: Some evidence for OA pain.
Boswellia: Some evidence for OA.
Avocado-soybean unsaponifiables (ASU): Some evidence; less commonly used.
For rheumatoid arthritis
Omega-3 fatty acids: Some evidence for RA inflammation. Higher doses needed (3+ g daily EPA+DHA).
Turmeric: Some evidence as adjunct.
Vitamin D: If deficient. May influence RA disease activity.
What doesn’t replace
For RA, disease-modifying medications (methotrexate, biologics, JAK inhibitors) are essential and shouldn’t be replaced by supplements. Supplements may serve as adjuncts.
Beyond supplements
- Weight management
- Physical therapy and exercise
- NSAIDs (with appropriate caution)
- Topical agents
- Disease-modifying drugs for inflammatory arthritis
Frequently Asked Questions
What works best for arthritis?
Depends on type. Lifestyle and prescription medications often most effective.
Does turmeric work for arthritis?
Some evidence, particularly with bioavailable formulations.
Should I take supplements with my RA medications?
Generally yes for omega-3 and turmeric. Discuss with rheumatologist.
Can supplements prevent arthritis?
Limited evidence. Lifestyle factors more important.
What about CBD for arthritis?
Some evidence. Quality control issues with OTC products.
The bottom line on arthritis supplements
Several supplements have modest evidence. Disease-modifying medications essential for inflammatory arthritis. Discuss with rheumatologist.