Acyclovir is standard antiviral therapy for herpes simplex virus in pregnancy. Is acyclovir safe in pregnancy has favorable answer based on substantial pregnancy data. Often used as suppressive therapy late in pregnancy to reduce neonatal transmission. Always discuss with your OB/GYN.
Pregnancy uses
- Acute herpes outbreaks
- Suppressive therapy from 36 weeks to delivery (reduces transmission risk)
- Treatment of varicella in pregnancy
Pregnancy safety
- Substantial data, no clear increase in birth defects
- Compatible with all trimesters
- Standard care for HSV-positive women near term
Valacyclovir alternative
Valacyclovir (prodrug of acyclovir) is also acceptable in pregnancy with similar safety. Often preferred due to easier dosing.
Acyclovir in breastfeeding
Compatible with breastfeeding.
Frequently Asked Questions
Should I take acyclovir suppression late in pregnancy?
Standard recommendation if you have HSV history. Reduces neonatal transmission.
Can I take acyclovir for outbreak in pregnancy?
Yes, treatment of acute outbreaks acceptable.
Is valacyclovir or acyclovir better?
Both acceptable. Valacyclovir easier dosing.
Can I breastfeed on acyclovir?
Yes.
What about HSV and delivery?
Active genital lesions at labor warrant cesarean delivery to prevent neonatal HSV.
The bottom line on acyclovir in pregnancy
Acyclovir is standard antiviral for HSV in pregnancy. Used for outbreaks and suppressive therapy. Compatible with breastfeeding.